diff --git a/src/tint/BUILD.gn b/src/tint/BUILD.gn
index 037793a..a51bd22 100644
--- a/src/tint/BUILD.gn
+++ b/src/tint/BUILD.gn
@@ -1126,6 +1126,7 @@
       "resolver/resolver_test_helper.cc",
       "resolver/resolver_test_helper.h",
       "resolver/side_effects_test.cc",
+      "resolver/static_assert_test.cc",
       "resolver/source_variable_test.cc",
       "resolver/storage_class_layout_validation_test.cc",
       "resolver/storage_class_validation_test.cc",
diff --git a/src/tint/CMakeLists.txt b/src/tint/CMakeLists.txt
index 5f93189..9a6a42d 100644
--- a/src/tint/CMakeLists.txt
+++ b/src/tint/CMakeLists.txt
@@ -809,6 +809,7 @@
     resolver/resolver_test_helper.h
     resolver/resolver_test.cc
     resolver/side_effects_test.cc
+    resolver/static_assert_test.cc
     resolver/source_variable_test.cc
     resolver/storage_class_layout_validation_test.cc
     resolver/storage_class_validation_test.cc
diff --git a/src/tint/resolver/dependency_graph.cc b/src/tint/resolver/dependency_graph.cc
index 36bff3f..2ddcaaa 100644
--- a/src/tint/resolver/dependency_graph.cc
+++ b/src/tint/resolver/dependency_graph.cc
@@ -204,6 +204,7 @@
             [&](const ast::Enable*) {
                 // Enable directives do not effect the dependency graph.
             },
+            [&](const ast::StaticAssert* assertion) { TraverseExpression(assertion->condition); },
             [&](Default) { UnhandledNode(diagnostics_, global->node); });
     }
 
@@ -315,6 +316,7 @@
                 TraverseExpression(w->condition);
                 TraverseStatement(w->body);
             },
+            [&](const ast::StaticAssert* assertion) { TraverseExpression(assertion->condition); },
             [&](Default) {
                 if (!stmt->IsAnyOf<ast::BreakStatement, ast::ContinueStatement,
                                    ast::DiscardStatement, ast::FallthroughStatement>()) {
@@ -515,6 +517,8 @@
             [&](const ast::TypeDecl* td) { return td->name; },
             [&](const ast::Function* func) { return func->symbol; },
             [&](const ast::Variable* var) { return var->symbol; },
+            [&](const ast::Enable*) { return Symbol(); },
+            [&](const ast::StaticAssert*) { return Symbol(); },
             [&](Default) {
                 UnhandledNode(diagnostics_, node);
                 return Symbol{};
@@ -533,11 +537,12 @@
     /// declaration
     std::string KindOf(const ast::Node* node) {
         return Switch(
-            node,                                               //
-            [&](const ast::Struct*) { return "struct"; },       //
-            [&](const ast::Alias*) { return "alias"; },         //
-            [&](const ast::Function*) { return "function"; },   //
-            [&](const ast::Variable* v) { return v->Kind(); },  //
+            node,                                                       //
+            [&](const ast::Struct*) { return "struct"; },               //
+            [&](const ast::Alias*) { return "alias"; },                 //
+            [&](const ast::Function*) { return "function"; },           //
+            [&](const ast::Variable* v) { return v->Kind(); },          //
+            [&](const ast::StaticAssert*) { return "static_assert"; },  //
             [&](Default) {
                 UnhandledNode(diagnostics_, node);
                 return "<error>";
@@ -549,9 +554,8 @@
     void GatherGlobals(const ast::Module& module) {
         for (auto* node : module.GlobalDeclarations()) {
             auto* global = allocator_.Create(node);
-            // Enable directives do not form a symbol. Skip them.
-            if (!node->Is<ast::Enable>()) {
-                globals_.emplace(SymbolOf(node), global);
+            if (auto symbol = SymbolOf(node); symbol.IsValid()) {
+                globals_.emplace(symbol, global);
             }
             declaration_order_.emplace_back(global);
         }
diff --git a/src/tint/resolver/resolver.cc b/src/tint/resolver/resolver.cc
index 64c3e03..4295bab 100644
--- a/src/tint/resolver/resolver.cc
+++ b/src/tint/resolver/resolver.cc
@@ -140,6 +140,7 @@
                 [&](const ast::TypeDecl* td) { return TypeDecl(td); },
                 [&](const ast::Function* func) { return Function(func); },
                 [&](const ast::Variable* var) { return GlobalVariable(var); },
+                [&](const ast::StaticAssert* sa) { return StaticAssert(sa); },
                 [&](Default) {
                     TINT_UNREACHABLE(Resolver, diagnostics_)
                         << "unhandled global declaration: " << decl->TypeInfo().name;
@@ -737,6 +738,33 @@
     return sem;
 }
 
+sem::Statement* Resolver::StaticAssert(const ast::StaticAssert* assertion) {
+    auto* expr = Expression(assertion->condition);
+    if (!expr) {
+        return nullptr;
+    }
+    auto* cond = expr->ConstantValue();
+    if (!cond) {
+        AddError("static assertion condition must be a constant expression",
+                 assertion->condition->source);
+        return nullptr;
+    }
+    if (auto* ty = cond->Type(); !ty->Is<sem::Bool>()) {
+        AddError(
+            "static assertion condition must be a bool, got '" + builder_->FriendlyName(ty) + "'",
+            assertion->condition->source);
+        return nullptr;
+    }
+    if (!cond->As<bool>()) {
+        AddError("static assertion failed", assertion->source);
+        return nullptr;
+    }
+    auto* sem =
+        builder_->create<sem::Statement>(assertion, current_compound_statement_, current_function_);
+    builder_->Sem().Add(assertion, sem);
+    return sem;
+}
+
 sem::Function* Resolver::Function(const ast::Function* decl) {
     uint32_t parameter_index = 0;
     std::unordered_map<Symbol, Source> parameter_names;
@@ -1042,6 +1070,7 @@
         [&](const ast::IncrementDecrementStatement* i) { return IncrementDecrementStatement(i); },
         [&](const ast::ReturnStatement* r) { return ReturnStatement(r); },
         [&](const ast::VariableDeclStatement* v) { return VariableDeclStatement(v); },
+        [&](const ast::StaticAssert* sa) { return StaticAssert(sa); },
 
         // Error cases
         [&](const ast::CaseStatement*) {
diff --git a/src/tint/resolver/resolver.h b/src/tint/resolver/resolver.h
index 10b5806..2b6a240 100644
--- a/src/tint/resolver/resolver.h
+++ b/src/tint/resolver/resolver.h
@@ -250,6 +250,7 @@
     sem::LoopStatement* LoopStatement(const ast::LoopStatement*);
     sem::Statement* ReturnStatement(const ast::ReturnStatement*);
     sem::Statement* Statement(const ast::Statement*);
+    sem::Statement* StaticAssert(const ast::StaticAssert*);
     sem::SwitchStatement* SwitchStatement(const ast::SwitchStatement* s);
     sem::Statement* VariableDeclStatement(const ast::VariableDeclStatement*);
     bool Statements(utils::VectorRef<const ast::Statement*>);
diff --git a/src/tint/resolver/static_assert_test.cc b/src/tint/resolver/static_assert_test.cc
new file mode 100644
index 0000000..3cb67c9
--- /dev/null
+++ b/src/tint/resolver/static_assert_test.cc
@@ -0,0 +1,110 @@
+// Copyright 2022 The Tint Authors.
+//
+// Licensed under the Apache License, Version 2.0 (the "License");
+// you may not use this file except in compliance with the License.
+// You may obtain a copy of the License at
+//
+//     http://www.apache.org/licenses/LICENSE-2.0
+//
+// Unless required by applicable law or agreed to in writing, software
+// distributed under the License is distributed on an "AS IS" BASIS,
+// WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+// See the License for the specific language governing permissions and
+// limitations under the License.
+
+#include "src/tint/resolver/resolver.h"
+
+#include "gmock/gmock.h"
+#include "src/tint/resolver/resolver_test_helper.h"
+
+using namespace tint::number_suffixes;  // NOLINT
+
+namespace tint::resolver {
+namespace {
+
+using ResolverStaticAssertTest = ResolverTest;
+
+TEST_F(ResolverStaticAssertTest, Global_True_Pass) {
+    GlobalStaticAssert(true);
+    ASSERT_TRUE(r()->Resolve()) << r()->error();
+}
+
+TEST_F(ResolverStaticAssertTest, Global_False_Fail) {
+    GlobalStaticAssert(Source{{12, 34}}, false);
+    EXPECT_FALSE(r()->Resolve());
+    EXPECT_EQ(r()->error(), "12:34 error: static assertion failed");
+}
+
+TEST_F(ResolverStaticAssertTest, Global_Const_Pass) {
+    GlobalConst("C", ty.bool_(), Expr(true));
+    GlobalStaticAssert("C");
+    ASSERT_TRUE(r()->Resolve()) << r()->error();
+}
+
+TEST_F(ResolverStaticAssertTest, Global_Const_Fail) {
+    GlobalConst("C", ty.bool_(), Expr(false));
+    GlobalStaticAssert(Source{{12, 34}}, "C");
+    EXPECT_FALSE(r()->Resolve());
+    EXPECT_EQ(r()->error(), "12:34 error: static assertion failed");
+}
+
+// TODO(crbug.com/tint/1581): Enable once the '<' operator is implemented for constant evaluation.
+TEST_F(ResolverStaticAssertTest, DISABLED_Global_LessThan_Pass) {
+    GlobalStaticAssert(LessThan(2_i, 3_i));
+    ASSERT_TRUE(r()->Resolve()) << r()->error();
+}
+
+// TODO(crbug.com/tint/1581): Enable once the '<' operator is implemented for constant evaluation.
+TEST_F(ResolverStaticAssertTest, DISABLED_Global_LessThan_Fail) {
+    GlobalStaticAssert(Source{{12, 34}}, LessThan(4_i, 3_i));
+    EXPECT_FALSE(r()->Resolve());
+    EXPECT_EQ(r()->error(), "12:34 error: static assertion failed");
+}
+
+TEST_F(ResolverStaticAssertTest, Local_True_Pass) {
+    WrapInFunction(StaticAssert(true));
+    ASSERT_TRUE(r()->Resolve()) << r()->error();
+}
+
+TEST_F(ResolverStaticAssertTest, Local_False_Fail) {
+    WrapInFunction(StaticAssert(Source{{12, 34}}, false));
+    EXPECT_FALSE(r()->Resolve());
+    EXPECT_EQ(r()->error(), "12:34 error: static assertion failed");
+}
+
+TEST_F(ResolverStaticAssertTest, Local_Const_Pass) {
+    GlobalConst("C", ty.bool_(), Expr(true));
+    WrapInFunction(StaticAssert("C"));
+    ASSERT_TRUE(r()->Resolve()) << r()->error();
+}
+
+TEST_F(ResolverStaticAssertTest, Local_Const_Fail) {
+    GlobalConst("C", ty.bool_(), Expr(false));
+    WrapInFunction(StaticAssert(Source{{12, 34}}, "C"));
+    EXPECT_FALSE(r()->Resolve());
+    EXPECT_EQ(r()->error(), "12:34 error: static assertion failed");
+}
+
+TEST_F(ResolverStaticAssertTest, Local_NonConst) {
+    GlobalVar("V", ty.bool_(), Expr(true), ast::StorageClass::kPrivate);
+    WrapInFunction(StaticAssert(Expr(Source{{12, 34}}, "V")));
+    EXPECT_FALSE(r()->Resolve());
+    EXPECT_EQ(r()->error(),
+              "12:34 error: static assertion condition must be a constant expression");
+}
+
+// TODO(crbug.com/tint/1581): Enable once the '<' operator is implemented for constant evaluation.
+TEST_F(ResolverStaticAssertTest, DISABLED_Local_LessThan_Pass) {
+    WrapInFunction(StaticAssert(LessThan(2_i, 3_i)));
+    ASSERT_TRUE(r()->Resolve()) << r()->error();
+}
+
+// TODO(crbug.com/tint/1581): Enable once the '<' operator is implemented for constant evaluation.
+TEST_F(ResolverStaticAssertTest, DISABLED_Local_LessThan_Fail) {
+    WrapInFunction(StaticAssert(Source{{12, 34}}, LessThan(4_i, 3_i)));
+    EXPECT_FALSE(r()->Resolve());
+    EXPECT_EQ(r()->error(), "12:34 error: static assertion failed");
+}
+
+}  // namespace
+}  // namespace tint::resolver
diff --git a/src/tint/resolver/uniformity.cc b/src/tint/resolver/uniformity.cc
index 555ea1a..9ccb7ef 100644
--- a/src/tint/resolver/uniformity.cc
+++ b/src/tint/resolver/uniformity.cc
@@ -847,6 +847,7 @@
                     return cfx;
                 }
             },
+
             [&](const ast::ReturnStatement* r) {
                 Node* cf_ret;
                 if (r->value) {
@@ -870,6 +871,7 @@
 
                 return cf_ret;
             },
+
             [&](const ast::SwitchStatement* s) {
                 auto* sem_switch = sem_.Get(s);
                 auto [cfx, v_cond] = ProcessExpression(cf, s->condition);
@@ -938,6 +940,7 @@
 
                 return cf_end ? cf_end : cf;
             },
+
             [&](const ast::VariableDeclStatement* decl) {
                 Node* node;
                 if (decl->variable->constructor) {
@@ -956,6 +959,11 @@
 
                 return cf;
             },
+
+            [&](const ast::StaticAssert*) {
+                return cf;  // No impact on uniformity
+            },
+
             [&](Default) {
                 TINT_ICE(Resolver, diagnostics_)
                     << "unknown statement type: " << std::string(stmt->TypeInfo().name);