diff --git a/src/dawn/tests/end2end/MultisampledSamplingTests.cpp b/src/dawn/tests/end2end/MultisampledSamplingTests.cpp
index c08ecc0..ac82523 100644
--- a/src/dawn/tests/end2end/MultisampledSamplingTests.cpp
+++ b/src/dawn/tests/end2end/MultisampledSamplingTests.cpp
@@ -51,6 +51,10 @@
     void SetUp() override {
         DawnTest::SetUp();
 
+        // TODO(crbug.com/tint/1976): DXC fails to compile the following compute shader because the
+        // coordinate in texture load is not interpreted as an integer vector.
+        DAWN_SUPPRESS_TEST_IF(IsD3D12() && HasToggleEnabled("use_dxc"));
+
         {
             utils::ComboRenderPipelineDescriptor desc;